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Amy Sedaris's film and television career began in the early 1990s, and since then she has appeared in a variety of films, television series and theatrical productions. Her vivid performances and ability to create unique characters made her one of the most recognizable and popular actresses in the comedy genre.

Some of Amy Sedaris' more famous works include:

- "Diary of a Weakling" (2010): In this comedy, she voiced the character Michelle, a classmate of the main character Greg Heffley.

- "Finding Nemo" (2003): Here she voiced the role of Florence, a whale.

- "Mad Men" (2001): In this film, she played the role of Jerry, the sister of one of the main characters.

Amy Sedaris continues to delight fans with her talented performances and continues to surprise with her professionalism and comic talent. Her contributions to the global film and comedy industry remain significant, and she remains one of the brightest stars in the genre.