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John began his film and stage career in the early 1980s. After graduating from high school, he entered the University of New York, where he studied drama and acting. During this time, he also began performing extensively in nightclubs in New York City, where he developed his skills as a comedian and performer.

John received his first prominent film roles in the mid-1990s. His talent was seen in films such as "Carlito Leaves" (1993) and "Romeo + Juliet" (1996), where he played roles with humor and intensity, for which he was recognized by critics and viewers.

Since then, John Leguizamo has starred in many films and television series, continuing to demonstrate his skill and talent. Some of his more famous works include:

- "Men" (1997): In this comedy, he played one of the main characters, bringing his unique humor and charisma to the film.

- "The X-Files" (2002): In this popular television series, he played the role of a computer specialist, adding notes of intrigue and mystery to the plot.

- "Dead Souls" (2019): In this thriller, he played the role of a mystery crime detective and emphasized his talent for creating memorable images.

In addition to his acting activities, John Leguizamo is also actively involved in social and charitable activities, supporting various initiatives to fight for equal rights and opportunities.

His talent, energy and dedication to the arts make him one of Hollywood's most influential and respected actors, and his work continues to inspire and entertain audiences around the world.